Evidation Health and Tueo Health Partner to Quantify Outcomes in Pediatric Asthma Patients Across the U.S.

A goal to breathe easier: Tueo Health and Evidation Health initiate recruiting parents of pediatric asthma patients for a pragmatic randomized clinical study

San Mateo, CA– Oct 18, 2017 – Evidation Health and Tueo Health have partnered together to quantify the clinical impact of a digital health solution on pediatric asthma management. They have recently started to virtually enroll parents of children with asthma into a 4-month randomized clinical study that is being conducted across the U.S.

One in ten children in the United States has asthma, and the prevalence is increasing. Pediatric asthma has been difficult to manage in the past, but new digital methods of passive monitoring hold promise in enabling parents to have greater influence over managing this chronic condition. Tueo Health has created a promising digital solution that combines sensor-based nocturnal monitoring, personalized analytics, a mobile education app, and an asthma coach to assist in better self-management. They looked to Evidation Health to run a robust clinical study to prove the impact of their solution on patient outcomes. 

The research partnership brings together Tueo’s digital health solution for monitoring and aiding in-home management of pediatric asthma with Evidation Health’s technology platform, health outcomes research capabilities, and behavior data analytics expertise to accelerate and enhance pediatric asthma outcomes research.

“As a physician, I know how important it is to show that our home-based asthma management solution results in improved asthma control,” said Tueo Founder and CEO, Bronwyn Harris, MD. “Evidation Health’s technology platform makes it possible for us to quantify the impact of our solution on representative pediatric asthma populations across the nation, faster than conventional trials in medical centers. A prior study took us a year to recruit the same number of patients that we have already recruited in the first two weeks!”

“Tueo’s digital health solution will provide powerful insights into asthma management, because of the view it provides into the real life experience of patients,” said Deb Kilpatrick, CEO of at Evidation Health. “In partnering with Tueo, we are combining our areas of expertise to deepen the understanding of pediatric asthma and the families who struggle with it, while optimizing truly novel interventions that will drive better patient outcomes.”

About Evidation Health

Evidation Health helps healthcare companies quantify outcomes in the digital era, with real life data from connected patients. The company developed its Real Life Study Platform to accelerate and enhance outcomes research through large-scale virtualized pragmatic trials– collecting novel digital signals and measuring the impact of digital health and traditional interventions far more efficiently than conventional approaches. Evidation Health works across the healthcare ecosystem with top pharmaceutical companies, payers, providers, and digital healthcare companies. Evidation Health is a privately held company headquartered in San Mateo, CA. For more information, visit www.evidation.com.

About Tueo Health

Tueo Health is a San Francisco-based company that has built a digital health solution to empower families to take better control of asthma management. The first Tueo solution is based on passive nocturnal monitoring, a mobile app, and targeted coaching and education, making it non-invasive and easy to use. Tueo won the Judge’s Choice award of the Plug and Play Tech Center Summer Summit 2017 and is part of the Stanford StartX Accelerator Program. More information on Tueo can be found at: www.tueohealth.com.

Contacts

Evidation Health

Polly Israni

press@evidation.com

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The What, Why, How and More of Clinical Studies

We are beginning a clinical study, an important step to show the value of our digital health solution and allow us to get firsthand user insight to improve the product. In preparing for this, it has become apparent to us that many people don’t understand what a clinical study is, why these studies are important, and how they can participate. We have put together the information in this post to help answer some of these questions.

 

What is a clinical study?

The National Institutes of Health (NIH) defines it this way:

Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. These studies also may show which medical approaches work best for certain illnesses or groups of people. Clinical trials produce the best data available for health care decision making.”

Now let’s discuss in more detail.

 

Why are clinical studies important?

Medical technologies and treatments are evolving rapidly, yet without clinical studies it isn’t possible to know for sure whether a specific treatment is better than another. It is also necessary to understand the limitations of treatments or diagnostic tools.

There have been unfortunate cases in the past where new medications or treatments became common without first being thoroughly evaluated in trials. Later, clinical trials revealed these things were actually harmful to patients. This has been seen a few times in treatment of patients with heart failure. This demonstrates that it is important to carefully study new interventions and treatments with a clinical study to understand the benefit and risks.

 

How do clinical studies work?

There are many types of studies, and each type works differently. Two of the most common are a randomized control trial and cohort study.

·      Randomized Control Trial - In this study, there are at least two groups and after a participant consents to be part of the study, they are randomly assigned into one of the groups. One group may be getting a treatment or therapy, such as a new medication or a tool to use, and the other group may simply continue their current care. Both groups will likely be monitored, whether by surveys or other measurements, to see if there are different results between the two groups. This type of study is important to know whether something new will actually help improve outcomes.

·      Cohort Study – This type of study (also called a prospective observational study) has two different groups of people that are being monitored over time. One group has a particular condition or received a specific exposure in the past and the participants in the other group don’t have that condition or did not receive the exposure. By following these two groups of participants over time and tracking differences, much can be learned about the effect of a disease or exposure.

 

Are there rules that clinical studies need to follow?

Yes, there are many rules that clinical studies need to adhere to. Clinical study rules were made to create standards that protect patients and help produce reliable study results.  For example, one rule is that each study needs to be reviewed by a board of experts (the Institutional Review Board, or IRB) to ensure the study is protecting the welfare of the participants and is properly informing them of the risks and benefits. So before a study is launched, a significant amount of effort is needed to ensure the study overall meets a strict set standards.

 

Who can participate?

This answer varies for each specific clinical study. When the trial is designed it is decided what group of people is going to be studied. There is often a restriction on age and medical condition. There can also be additional requirements that vary from location of the individual, what medications are being taken, to how severe the condition. There are usually screening questions to determine eligibility before you can consent for a clinical trial.

 

Where can I find a clinical trial that I can participate in?

There are many different ways to find clinical trials and potentially participate. 

·      ClinicalTrials.gov - is sponsored by the NIH and is a place where clinical studies all around the world can be registered. You can search by specific condition and country. For example if you are looking for a study for your child with asthma.

·      Centerwatch - has trial listings and will allow you to sign up for e-mail notifications for new trials that you may be eligible for.

·      Local medical centers – local centers often have a list of studies that are being run at their location.  

·      Groups for specific medical conditions may also have lists of current trials.

Choosing to participate in a clinical trial can be a big decision and should be made very carefully, but given the importance of these studies for the progress of medical science, if you do choose to participate in one you can do so knowing that you’re indirectly helping many other people.

 

Let us know if you have any additional questions, e-mail us at engage@tueohealth.com.

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If you’d be interested to learn more about Tueo’s clinical study for children with asthma, click here.

Tueo Health Selected by StartX to Participate in Accelerator Program

Tueo Gains Access to Vast Network of Resources to Drive Growth

SAN FRANCISCO, September 8, 2017 — Tueo Health, a digital health start-up company that has developed a unique solution for monitoring and aiding in home management of pediatric asthma, today announced that StartX has awarded Tueo a position in their Fall 2017 accelerator program. StartX is an educational non-profit that accelerates the development of Stanford's top entrepreneurs through tactical help and resources, experiential education, funding, and a vast network of mentors, investors, and domain experts. StartX has supported 1000+ founders, 450 startups, and raised over $2.9B. Only 8-10% of applicants are selected into each program.

The founders of Tueo Health came together as fellows in the Stanford Biodesign Innovation Fellowship, a ten-month program focused on needs-based health technology innovation. The team began looking at the important need in asthma management during the fellowship, starting the early work, including a clinical study at Stanford that has now been translated into the Tueo Health solution.

Myself and my co-founders are thrilled to be selected for the StartX accelerator program,” said Tueo Founder and CEO, Bronwyn Harris, MD.  “The access to the community, world class advisors, and a variety of business resources is invaluable to Tueo’s success and we are honored to have been chosen.”

StartX judges focus on evaluating the team, during a stringent and extensive written application and interview process. Tueo was selected based on criteria that includes: passion and commitment demonstrated by the founders, team dynamics, ability to execute and core competency, and willingness to understand the target market. More information on StartX can be found at: www.startx.com.

About Tueo Health

Tueo Health is a San Francisco-based company that is building the first digital health solution to empower families to take better control of asthma management. The first Tueo solution is based on passive nocturnal monitoring, a mobile app, and targeted coaching and education, making it non-invasive and easy to use. Tueo was the Judge’s Choice winner of the Plug and Play Tech Center Summer Summit 2017. More information on Tueo can be found at: www.tueohealth.com.

 

Tueo Health Oversubscribes Seed Round to Support Clinical Study and Growth

Digital Health Start-Up Helps Manage Pediatric Asthma

SAN FRANCISCO, July 24, 2017Tueo Health, a digital health start-up company that has developed a unique solution for monitoring and managing pediatric asthma, has closed $1.1 million in seed round funding. The seed financing was led by Launchpad Digital Health, with participation from Plug and Play, and other strategic angel investors.

“Asthma is a costly chronic disease that affects more than 7 million children in the US alone,” said Tueo Founder and CEO, Bronwyn Harris, MD.  “Over half of asthma related direct healthcare costs are from hospital-based care that could be avoided by better asthma control.”

According to Harris, poor asthma control not only increases healthcare utilization, but results in missed school days, impaired academic performance, and lower overall quality of life. “Tueo Health empowers families to better manage their child’s asthma,” says Harris.

“New methods of passive monitoring make real control of debilitating conditions possible, and Tueo Health is leading this effort in conditions of the lungs,” said Fred Toney, CEO of Launchpad Digital Health. “With smart inhalers, we can now begin to better measure dosing of drugs, but Tueo provides the critical information necessary on a daily basis to assess how the patient is responding. This valuable data-driven approach will transform the way we treat chronic diseases such as asthma, COPD and others.”

Currently families are tasked with monitoring and managing their child’s health but lack the information and tools they need to do this effectively. To address this need, Tueo Health has created an integrated solution that combines sensor-based nocturnal monitoring; personalized analytics based on physiologic data; a mobile app that delivers data and provides educational and clinical context; and an asthma coach that assists in self-management. Prompts and guidance are based on guidelines from the National Asthma Education and Prevention Program.

“As a parent of a child with asthma, it makes me sad that so many children are limited by the disease,” said Harris, who is both a biomedical engineer and pediatric cardiologist. “At Tueo Health, we believe that families shouldn’t be held hostage by asthma. We are leveraging technological advancements to create the data and tools families need to manage the condition and improve quality of life,” she said.

Tueo will use the new financing to conduct a clinical study starting in September and drive continued application development and market positioning.

The founders of Tueo Health came together as fellows in the Stanford Biodesign Innovation Fellowship, a ten-month program focused on needs-based health technology innovation. The team began looking at this important need in asthma management during the fellowship, starting the early work, including a clinical study at Stanford that has now been translated into the Tueo Health solution.

About Tueo Health

Tueo Health is a San Francisco-based company that is building the first digital health solution to empower families to take better control of asthma management. The first Tueo solution is based on passive nocturnal monitoring, a mobile app, and targeted coaching and education, making it non-invasive and easy to use. Tueo was the Judge’s Choice winner of the Plug and Play Tech Center Summer Summit 2017. More information on Tueo can be found at: www.tueohealth.com.

About Launchpad Digital Health

Launchpad Digital Health is the most active seed stage fund for digital health in the U.S.  Its unique side-by-side immersion program, which outperforms traditional accelerator programs, includes more capital, more time and more intensity for its portfolio companies and their founders.  The founders and senior leadership of Launchpad Digital Health have funded and operated companies throughout the healthcare and technology sectors, including digital health companies, for the past two decades.

Inhaler Technique

This latest post comes straight from our CEO Bronwyn Harris. Bronwyn is a physician and also the mother of a child with asthma.

Inhalers are awesome, but tricky!

I take for granted the inhaler that I give my daughter, but when I take a moment I can appreciate what a great invention it is. For many other conditions, such as heart disease, you have to swallow a pill, and it goes through your blood stream -- often spreading to the whole body -- before it can have an effect on a specific location (e.g. heart or blood vessels). An inhaler allows medicine to go quickly and directly to your lungs where it is needed!  This allows for quick action and less side effects overall.

As tremendous as they are, inhalers do have an Achilles’ heel: they aren’t easy to take, especially for children. Recent research from a team at Rice University highlighted in a Wall Street Journal article found that 70-90% (!) of people don’t use their inhaler appropriately, resulting in less medication getting to their lungs. This led me to actually read the packaging the next time I picked up my daughter’s new inhaler. The instructions, printed on that thin tissue type of paper, opened as big as a fold-up map (anyone remember what those are?)!  There are eight steps listed and steps 2-6 have to be repeated for the second puff. It definitely is more complicated than just swallowing a pill. Really reading through the instructions carefully for the first time I realized that I wasn’t shaking it for five seconds as directed, so I was in that 70% that had wrong technique! If you or someone you care for has asthma, I encourage you to take a moment and review your inhaler technique – there are many great online resources, here’s one that looked good to me. Remember that taking your medications regularly and correctly are an important step in maintaining asthma control!

World Asthma Day

The first Tuesday of May (today!), is World Asthma Day, organized by GINA -- the Global Initiative for Asthma -- with the goal of improving asthma awareness. While most people have heard of asthma and may know someone who is affected by it, many people do not understand it well. We have compiled a few basics here to do our part in promoting awareness and understanding.

  • Asthma is common, 1 in 12 people (about 25 million people in the U.S), and the prevalence is growing.
  • There is no cure for asthma, but it can be controlled, so having asthma doesn’t have to mean strict limits on lifestyle. Many notable athletes manage the disease, including professional football player Jerome Bettis, a six-time Pro-Bowl running back!  This old advertisement featuring “The Bus” brought us some smiles in the office -- especially for those with Pittsburgh connections.
  • When asthma is controlled it means that the person has no asthma symptoms (or only infrequent, mild symptoms) and can perform all of their normal activities. When asthma is not well controlled there is a higher likelihood of experiencing an exacerbation (or asthma attack).

Despite the incredible wealth of information about the disease, for many people one big challenge of controlling asthma remains the lack of a gold standard measurement of asthma control. At Tueo Health we’re doing our best to change that – stay tuned!

 

What we're reading: assessing asthma control

From the "What We're Reading" series, here's a look at a recent publication in the journal Pediatrics from Dinakar, et al titled "Clinical Tools to Assess Asthma Control in Children." You can find it on PubMed here.

The abstract nicely summarizes the current standard for clinical tools to assess asthma control.  It states, "The nuances of estimation of asthma control include understanding concepts of current impairment and future risk and incorporating their measurement into clinical practice, "and goes on to note that many of the "currently available ambulatory tools to measure asthma control range are subjective measures" and that, "health care providers need to be vigilant" in order to "to choose the optimal set of measures that will adhere to national standards of care and ensure delivery of high-quality care customized to their patients"

When we see the words nuance, subjective, and vigilance all tied to the current standards for managing a serious chronic disease we see tremendous room for improvement, and we're looking forward to the day when we can bring clear, objective metrics to bear on this problem in a way that inspires confidence and gives everyone -- parents, children, and healthcare providers -- a chance to breathe a little easier.

3...2...1...

Tueo Health is excited to announce closing on its first equity financing in partnership with Launchpad Digital Health! Originating with research in the Stanford Biodesign program in 2014 our team has been building towards takeoff and the funding is a big step forward in our mission to bring improved asthma management to patients everywhere. The Tueo team will be sitting in-house with Launchpad's team of mentors and a dynamic group of other digital health companies in the heart of San Francisco for 2017. Come visit!

Launchpad Digital Health

Launchpad Digital Health

Congratulations to our research partners

We're happy to share the news that our collaborators at Stanford have been awarded a grant from Spectrum, the Stanford Center for Clinical and Translational Research and Education to extend an observational study initiated by the Tueo Health team while part of the Stanford Biodesign program. The study is titled "Passive home monitor for objective measures of asthma control in children," and is building a foundation of evidence for key parts of Tueo's innovative concept for asthma management. Dr. David Cornfield, director of Pulmonary Medicine at Stanford and a pediatric pulmonologist at Lucile Packard Children's Hospital Stanford is the Principal Investigator and is supported by Dr. Michelle Huffaker, a postdoctoral scholar in allergy and immunology.

More details on the many exciting projects funded by Spectrum are in this announcement.